Author

D. N. Sather

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 10 Assay:proteomics· 7 Organism:human· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:differential expression· 2

Frequent Co-Authors

V. Vigdorovich· 9 shared N. Dambrauskas· 6 shared A. Raappana· 4 shared A. Watson· 3 shared S. Carbonetti· 3 shared S. H. I. Kappe· 3 shared A. B. Ward· 2 shared A. Kaushansky· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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9 shared papersImmunology

V. Vigdorovich

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct omicron SARS-CoV-2 subvariants

S. Changrob, P. J. Halfmann, H. Liu, J. L. Torres, J. J. C. McGrath, G. Ozorowski, L. Li, M. Kuroda, T. Maemura, M. Huang, D. G. Wilbanks, N.-Y. Zheng, H. L. Turner, S. A. Erickson, Y. Fu, , P. C. Wilson

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

bioRxiv · Oct 31, 2022Immunology

Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection.

V. Vigdorovich, H. Patel, A. Watson, A. Raappana, L. Reynolds, W. Selman, S. Beeman, P. T. Edlefsen, S. H. I. Kappe, D. N. Sather

This paper shows that combining multiple pre-erythrocytic antigens with CSP enhances sterile protection against Plasmodium sporozoite infection in a mouse model.

bioRxiv · Jun 17, 2022 · PreprintImmunology

Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and enhance protection of anti-CSP monoclonal antibodies

B. K. Wilder, V. Vigdorovich, S. Carbonetti, N. Minkah, N. Hertoghs, A. Raappana, H. Cardamone, B. G. Oliver, O. Trakhimets, S. Kumar, N. Dambrauskas, S. A. Arredondo, N. Camargo, S. H. I. Kappe, D. N. Sather

This study shows that anti-TRAP/SSP2 monoclonal antibodies inhibit sporozoite infection and enhance protection from CSP-based antibodies, suggesting a multivalent vaccine strategy could improve malaria vaccines.

bioRxiv · Oct 15, 2021 · PreprintMicrobiology

Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection

G. R. Visweswaran, K. Vijayan, R. Chandrasekaran, O. Trakhimets, S. L. Whiteside, V. Vigdorovich, A. Yang, A. Raappana, A. Watson, W. Selman, M. Zuck, N. Dambrauskas, A. Kaushansky, D. N. Sather

This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.

bioRxiv · Sep 10, 2021 · PreprintImmunology

Vaccination with B.1.1.7, B.1.351 and P.1 variants protects mice from challenge with wild type SARS-CoV-2

F. Amanat, S. Strohmeier, P. Meade, N. Dambrauskas, B. Mühlemann, D. J. Smith, V. Vigdorovich, D. N. Sather, L. Coughlan, F. Krammer

This study evaluates cross-neutralizing antibody responses and protective efficacy of vaccines based on SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 in mice against wild type SARS-CoV-2 challenge.

bioRxiv · Aug 5, 2021 · PreprintImmunology

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2

F. D. Mast, P. C. Fridy, N. E. Ketaren, J. Wang, E. Y. Jacobs, J. P. Olivier, T. Sanyal, K. R. Molloy, F. Schmidt, M. Rutkowska, Y. Weisblum, L. M. Rich, E. R. Vanderwall, N. Dambrauskas, V. Vigdorovich, , M. P. Rout

This paper presents a large repertoire of high-affinity nanobodies against SARS-CoV-2 Spike protein with potent neutralization properties and resistance to viral variants.

bioRxiv · Apr 8, 2021Biochemistry

Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques

M. P. Wood, C. I. Jones, A. Lippy, B. G. Oliver, B. Walund, K. A. Fancher, B. S. Fisher, P. J. Wright, J. T. Fuller, P. Murapa, J. Habib, M. Mavigner, A. Chahroudi, D. N. Sather, D. H. Fuller, D. Sodora

This study identifies lymphoid follicle dysfunction as a key factor in rapid disease progression in SIV-infected infant rhesus macaques.

bioRxiv · Dec 31, 2020Immunology

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage

K. Vijayan, R. Chandrasekaran, O. T. Trakhimets, S. L. Brown, N. Dambrauskas, M. Zuck, G. R. R. Visweswaran, A. Watson, A. Raappana, S. Carbonetti, L. Kelnhofer-Millevolte, E. K. K. Glennon, R. Postiglione, D. N. Sather, A. Kaushansky

This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.

bioRxiv · Sep 15, 2020Immunology

Platelet Derived Growth Factor Receptor β (PDGFRβ) is a Host Receptor for the human malaria parasite adhesin TRAP

R. W. J. Steel, V. Vigdorovich, N. Dambrauskas, B. K. Wilder, S. A. Arredondo, D. Goswami, S. Kumar, S. Carbonetti, K. E. Swearingen, T. Nguyen, W. Betz, N. Camargo, B. S. Fisher, J. Soden, H. Thomas, , S. H. I. Kappe

The paper identifies hPDGFRβ as a host receptor for the malaria parasite TRAP, showing its role in sporozoite motility and infection.

bioRxiv · May 12, 2020Microbiology

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

C. A. Cottrell, J. van Schooten, C. A. Bowman, M. Yuan, D. Oyen, M. Shin, R. Morpurgo, P. van der Woude, M. van Breemen, J. L. Torres, R. Patel, J. Gross, L. M. Sewall, J. Copps, G. Ozorowski, , M. J. van Gils

This study maps antibody responses to HIV-1 envelope trimers in non-human primates, identifying strain-specific and conserved epitopes recognized by vaccine-induced antibodies.

bioRxiv · Feb 5, 2020Immunology

Diversity and function of maternal HIV-1-specific antibodies at the time of vertical transmission

L. Doepker, C. Simonich, D. Ralph, T. A. Gobillot, M. Garrett, V. Vigdorovich, D. N. Sather, R. Nduati, F. Matsen, J. Overbaugh

This study isolates and characterizes HIV-specific neutralizing antibodies from a mother of a vertically infected infant, revealing their diversity and functional properties.

bioRxiv · Sep 23, 2019Immunology

Rapid development of an infant-derived HIV-1 broadly neutralizing antibody lineage

C. A. Simonich, L. Doepker, D. Ralph, J. A. Williams, A. Dhar, Z. Yaffe, L. Gentles, C. T. Small, B. Oliver, V. Vigdorovich, V. Mangala Prasad, R. Nduati, D. N. Sather, K. K. Lee, F. A. Matsen, J. Overbaugh

This study reconstructs the developmental lineage of an infant-derived HIV-1 broadly neutralizing antibody, showing a rapid evolution with fewer mutations compared to adult antibodies.

bioRxiv · Sep 13, 2018Immunology