Author

S. V. Owen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Bioengineering· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

J. C. D. Hinton· 5 shared M. Baym· 4 shared R. Canals· 4 shared M. A. Gordon· 3 shared N. Quinones-Olvera· 3 shared N. Wenner· 3 shared C. Kröger· 2 shared D. L. Hammarlöf· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersMicrobiology

J. C. D. Hinton

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Author profile →

10 papers

Recent·Most cited

Diverse and Abundant Phages Exploit Conjugative Plasmids

N. Quinones-Olvera, S. V. Owen, L. M. McCully, M. G. Marin, E. A. Rand, A. C. Fan, O. J. M. Dosumu, K. Paul, C. E. S. Castano, R. Petherbridge, J. S. Paull, M. Baym

This study identifies diverse and abundant plasmid-dependent phages in wastewater, revealing their underappreciated role in constraining horizontal gene transfer.

bioRxiv · Mar 19, 2023Microbiology

Parallel evolution of mutational fitness effects over 50,000 generations

A. Limdi, S. V. Owen, C. Herren, R. E. Lenski, Michael Baym

The study examines how mutation fitness effects change over 50,000 generations in E. coli, finding parallel evolution of mutation costs and increased essentiality without altering the overall fitness landscape distribution.

bioRxiv · May 17, 2022Evolutionary Biology

The gut bacterial natural product colibactin triggers induction of latent viruses in diverse bacteria

J. E. Silpe, J. W. H. Wong, S. V. Owen, M. Baym, E. P. Balskus

This study shows colibactin induces prophage lytic development in bacteria, with resistance mechanisms observed across diverse taxa.

bioRxiv · May 24, 2021 · PreprintMicrobiology

Prophage-encoded phage defence proteins with cognate self-immunity

S. V. Owen, N. Wenner, C. L. Dulberger, E. V. Rodwell, A. Bowers-Barnard, N. Quinones-Olvera, D. J. Rigden, E. J. Rubin, E. C. Garner, M. Baym, J. C. D. Hinton

The paper identifies BstA, a prophage-encoded phage defense protein that suppresses phage epidemics through abortive infection, with self-immunity mediated by the anti-BstA element.

bioRxiv · Jul 13, 2020Microbiology

Forensic microbial system for high-resolution object provenance

J. Qian, Z.-x. Lu, C. P. Mancuso, H.-Y. Jhuang, R. d. C. Barajas-Ornelas, S. Boswell, F. H. Ramirez-Guadiana, V. Jones, A. Sonti, K. Sedlack, L. Artzi, G. Jung, M. Arammash, M. Melfi, L. Lyon, , M. Springer

This paper develops a synthetic microbial spore system for high-resolution object provenance tracking with rapid decoding and biocontainment.

bioRxiv · Mar 14, 2020 · PreprintBioengineering

A window into lysogeny: Revealing temperate phage biology with transcriptomics

S. V. Owen, R. Canals, N. Wenner, D. L. Hammarlöf, C. Kröger, J. C. D. Hinton

The paper uses bacterial RNA-seq data to identify novel prophage accessory loci by analyzing transcriptional landscapes of Salmonella prophages.

bioRxiv · Sep 30, 2019Microbiology

African Salmonella Typhimurium sequence type 313 lineage 2 evades MAIT cell recognition by overexpressing RibB

L. Preciado-Llanes, A. Aulicino, R. Canals, P. Moynihan, X. Zhu, N. Jambo, T. Nyirenda, I. Kadwala, S. V. Owen, N. Veerapen, G. S. Besra, M. A. Gordon, J. C. D. Hinton, G. Napolitani, M. Salio, A. Simmons

The paper shows African S. Typhimurium lineage 2 strains evade MAIT cell recognition by overexpressing ribB, which may contribute to their pathogenicity.

bioRxiv · Sep 10, 2019Immunology

The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid

R. Canals, R. R. Chaudhuri, R. E. Steiner, S. V. Owen, N. Quinones-Olvera, M. A. Gordon, M. Ibba, J. C. D. Hinton

The paper uses transposon insertion sequencing to analyze the fitness landscape of Salmonella Typhimurium ST313 strain D23580, identifying essential genes and plasmid-encoded factors affecting growth and macrophage infection.

bioRxiv · Jul 1, 2019Microbiology

Adding function to the genome of African Salmonella ST313

R. Canals, D. L. Hammarlöf, C. Kröger, S. V. Owen, W. Y. Fong, L. Lacharme-Lora, X. Zhu, N. Wenner, S. E. Carden, J. Honeycutt, D. M. Monack, R. A. Kingsley, P. Brownridge, R. R. Chaudhuri, W. P. M. Rowe, , J. Hinton

The paper compares genomic and transcriptomic differences between Salmonella ST313 and ST19 isolates to identify phenotypic variations and a novel plasmid maintenance system.

bioRxiv · Oct 22, 2018Microbiology

Salmonella enterica Serovar Typhimurium ST313 Responsible For Gastroenteritis In The UK Are Genetically Distinct From Isolates Causing Bloodstream Infections In Africa

P. M. Ashton, S. V. Owen, L. Kaindama, W. P. M. Rowe, C. Lane, L. Larkin, S. Nair, C. Jenkins, E. de Pinna, N. Feasey, J. C. D. Hinton, T. Dallman

This paper identifies genetically distinct ST313 Salmonella isolates causing gastroenteritis in the UK and invasive disease in Africa, highlighting their evolutionary divergence and adaptation to different environments.

bioRxiv · May 19, 2017Microbiology