M. Yadav

A resource to enable chemical biology and drug discovery of WDR Proteins

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

This paper shows telomere length regulates hTERT expression by modulating TRF2 binding and PRC2-mediated repression, revealing a self-regulatory mechanism in cancer.

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

This study presents cryo-EM structures of GPR109A-G-protein complexes with agonists and uses them to engineer biased agonists with reduced flushing effects.

Structural insights into ligand-recognition, activation, and signaling-bias at the complement C5a receptor, C5aR1

This study presents cryo-EM structures of C5aR1 bound to C5a and a synthetic peptide, revealing conformational changes and G-protein coupling mechanisms.

Selective binding and transport of protocadherin 15 isoforms by stereocilia unconventional myosins in a heterologous expression system

The paper investigates the selective transport of PCDH15 isoforms by specific myosins in a heterologous system, revealing isoform-specific transport patterns.

Microliter spotting and micro-colony observation: a rapid and simple approach for counting bacterial colony-forming units

This paper introduces a rapid method for counting bacterial colony-forming units using micro-colony observation, achieving results comparable to traditional dilution plating with reduced time and labor.

OsbZIP62/OsFD7, a functional ortholog of Flowering Locus D (FD), regulates floral transition and panicle development in rice

This study identifies OsbZIP62/OsFD7 as a rice gene that regulates floral transition and panicle development by interacting with flowering regulators and affecting gene expression.

Genome-Wide High Resolution Expression Map and Functions of Key Cell Fate Determinants Reveal the Dynamics of Crown Root Development in Rice

The paper identifies key regulators of crown root development in rice and reveals conserved mechanisms across plant species.

Identification of miRNAs and their corresponding mRNA targets from chickpea nodules and functional characterization of candidate miRNAs by overexpression in chickpea roots

The paper identifies miRNAs and their mRNA targets in chickpea nodules and functionally characterizes selected miRNAs through overexpression in chickpea roots, revealing novel miRNA-target pairs and bacterial-derived small RNAs.