Author

V. Natarajan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 1 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

R. S. Gokhale· 4 shared F. Sultan· 3 shared Y. J. Subramaniam· 3 shared A. Singh· 2 shared C. R. Simoneau· 2 shared D. Murthy· 2 shared J. L. Baron· 2 shared M. Ott· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCell Biology

R. S. Gokhale

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Sustained pigmentation causes DNA damage and invokes translesion polymerase Pol κ for repair in melanocytes

V. Natarajan, S. Khanna, M. Ghazi, Y. J. Subramaniam, I. Gupta, F. Sultan, K. Sharma, S. Chandna, R. S. Gokhale

This study shows sustained melanogenesis causes DNA damage in melanocytes, invokes Pol κ for repair, and links Pol κ activity to genome instability and mutational load in melanoma.

bioRxiv · May 20, 2022 · PreprintCell Biology

Hepatitis C Virus Infects and Perturbs Liver Stem Cells

N. L. Meyers, T. Ashuach, D. E. Lyons, C. R. Simoneau, A. L. Erickson, T. T. Nguyen, M. Bouhaddou, M. M. Khalid, T. Y. Taha, V. Natarajan, J. L. Baron, N. Neff, F. Zanini, T. Mahmoudi, S. R. Quake, , M. Ott

This study identifies liver stem cells as targets of HCV infection, showing their transcriptional reprogramming and role in liver damage and cancer risk.

bioRxiv · Oct 26, 2021Microbiology

Liver Organoid and T Cell Coculture Models Cytotoxic T Cell Responses against Hepatitis C Virus

V. Natarajan, C. R. Simoneau, A. Erickson, N. L. Meyers, J. L. Baron, S. Cooper, M. Ott, T. C. McDevitt

This paper develops a microfluidic coculture system of liver organoids and T cells to study HCV-specific cytotoxic T cell responses in vitro.

bioRxiv · Aug 10, 2021 · PreprintImmunology

Temporal resolution of melanogenesis determine fatty acid metabolism as key skin pigment regulator

R. S. Gokhale, F. Sultan, R. BASU, D. Murthy, M. KOCHAR, K. S. ATTRI, A. AGGARWAL, P. Kumari, P. DNYANE, A. Singh, C. J. Gadgil, N. S. Bhavesh, P. K. singh, V. Natarajan

The paper identifies fatty acid metabolism as a key regulator of melanogenesis by analyzing temporal metabolic and transcriptional changes in melanocytes.

bioRxiv · Apr 6, 2021 · PreprintCell Biology

kinesin recruitment by adapter SKIP on melanosomes is dynamically controlled by LC3B phosphorylation

Y. J. Subramaniam, D. Murthy, A. D. Raja, A. Ramkumar, S. Sivasubbu, D. G. McEwan, R. S. Gokhale, V. Natarajan

This study identifies KIF1B as a novel kinesin motor for melanosome transport and shows that LC3B phosphorylation by PKA enhances anterograde movement in response to -MSH.

bioRxiv · Mar 11, 2021 · PreprintCell Biology

Matrix Stiffness Regulates Liver Sinusoidal Endothelial Cell Function Mimicking Responses in Fatty Liver Disease

V. Natarajan, M. Moeller, C. Casey, E. Harris, S. Kidambi

This study shows that increased matrix stiffness in fibrotic environments alters LSEC function, leading to capillarization and loss of endocytic ability, contributing to liver fibrosis progression.

bioRxiv · Jan 27, 2020 · PreprintBioengineering

Tunability of DNA polymerase stability during eukaryotic DNA replication

J. S. Lewis, L. M. Spenkelink, G. D. Schauer, O. Yurieva, S. H. Mueller, V. Natarajan, G. Kaur, C. Maher, C. Kay, M. E. O'Donnell, A. M. van Oijen

The paper shows how DNA polymerase stability and exchange dynamics in the yeast replisome are tuned by local concentrations, enabling efficient replication and adaptation to genomic challenges.

bioRxiv · Jun 7, 2019Biophysics

pH controlled histone acetylation amplifies melanocyte differentiation program downstream of MITF

V. Natarajan, D. A. Raja, V. Gotherwal, Y. J. Subramaniam, F. Sultan, A. Vats, A. Singh, S. Sivasubbu, R. S. Gokhale

The paper identifies a pH-controlled histone acetylation mechanism downstream of MITF that amplifies melanocyte differentiation by modulating chromatin dynamics.

bioRxiv · Feb 8, 2019Cell Biology