Author

R. Sebastian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Thomas· 2 shared D. Atkinson· 2 shared L. Pongor· 2 shared M. Aladjem· 2 shared N. Takahashi· 2 shared S. Kumar· 2 shared Y. Pommier· 2 shared Y. Zhang· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

A. Thomas

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3 papers

Recent·Most cited

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

P. A. Desai, N. Takahashi, R. Kumar, S. Nichols, J. Malin, A. Hunt, C. Schultz, Y. Cao, D. Tillo, D. Nousome, L. Chauhan, L. Sciuto, K. Jordan, V. Rajapakse, D. Lissa, , R. El Meskini

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

bioRxiv · Feb 9, 2024Cancer Biology

ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer

C. W. Schultz, Y. Zhang, R. Elmeskini, A. Zimmermann, H. Fu, Y. Murai, D. Wangsa, S. Kumar, N. Takahashi, D. Atkinson, L. K. Saha, C.-F. Lee, B. Elenbaas, P. Desai, R. Sebastian, , A. Thomas

This study shows that combining ATR inhibition with lurbinectedin improves efficacy in SCLC, particularly in MYC-driven non-neuroendocrine tumors.

EMBO Molecular Medicine · Aug 7, 2023Peer-reviewedCancer Biology

SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signatures

C. Tlemsani, L. Pongor, L. Girard, N. Roper, F. Elloumi, S. Varma, A. Luna, V. N. Rajapakse, R. Sebastian, K. W. Kohn, J. Krushkal, M. Aladjem, B. Teicher, P. S. Meltzer, W. C. Reinhold, , Y. Pommier

SCLC_CellMiner provides an integrated resource of 118 SCLC cell lines with omics data and drug sensitivity, identifying molecular subtypes and therapeutic targets.

bioRxiv · Mar 9, 2020 · PreprintCancer Biology