Author

R. T. Eguia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:deep learning· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. D. Bloom· 5 shared H. Y. Chu· 3 shared A. J. Greaney· 2 shared A. N. Loes· 2 shared A. Sigal· 2 shared D. Corti· 2 shared D. Veesler· 2 shared J. K. Logue· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

J. D. Bloom

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5 papers

Recent·Most cited

Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin

F. C. Welsh, R. T. Eguia, J. M. Lee, H. K. Haddox, J. Galloway, N. V. Vinh, A. N. Loes, J. Huddleston, T. C. Yu, M. Q. Le, N. T. Nhat, N. T. L. Thanh, A. L. Greninger, H. Y. Chu, J. A. Englund, , J. D. Bloom

The paper maps how HA mutations affect neutralization by serum from different age groups, showing age-dependent antigenic effects and implications for viral evolution.

bioRxiv · Dec 12, 2023Microbiology

The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes

A. J. Greaney, R. T. Eguia, T. N. Starr, K. Khan, N. Franko, J. K. Logue, S. M. Lord, C. Speake, H. Y. Chu, A. Sigal, J. D. Bloom

The paper examines the antibody response to the SARS-CoV-2 Delta variant, showing it targets class 1 and 2 epitopes more than class 3, and that mutations in these regions reduce antibody binding.

bioRxiv · Mar 12, 2022Microbiology

Structure, receptor recognition and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

M. A. Tortorici, A. C. Walls, A. Joshi, Y.-J. Park, R. T. Eguia, T. Stevens-Ayers, M. J. Boeckh, A. Talenti, A. Lanzavecchia, D. Corti, J. D. Bloom, D. Veesler

The paper determines the structure of the CCoV-HuPn-2018 spike glycoprotein, identifies its receptor, and shows cross-neutralizing antibodies against related coronaviruses.

bioRxiv · Oct 25, 2021Microbiology

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

A. J. Greaney, T. N. Starr, R. T. Eguia, A. N. Loes, K. Khan, F. Karim, S. Cele, J. E. Bowen, J. K. Logue, D. Corti, D. Veesler, H. Y. Chu, A. Sigal, J. D. Bloom

This study compares antibody responses to early SARS-CoV-2 isolates and the B.1.351 variant, finding shifts in immunodominance hierarchy within the spike receptor-binding domain.

bioRxiv · Oct 12, 2021Microbiology

Comprehensive profiling of mutations to influenza virus PB2 that confer resistance to the cap-binding inhibitor pimodivir

Y. Q. S. Soh, K. D. Malone, R. T. Eguia, J. D. Bloom

This study maps all single-amino-acid mutations in avian PB2 conferring resistance to pimodivir, identifying known and novel mutations in multiple domains.

bioRxiv · May 11, 2021Microbiology