Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
A. J. Greaney, T. N. Starr, R. T. Eguia, A. N. Loes, K. Khan, F. Karim, S. Cele, J. E. Bowen, J. K. Logue, D. Corti, D. Veesler, H. Y. Chu, A. Sigal, J. D. Bloom
This study compares antibody responses to early SARS-CoV-2 isolates and the B.1.351 variant, finding shifts in immunodominance hierarchy within the spike receptor-binding domain.
bioRxiv · Oct 12, 2021Microbiology
L. Jackson, H. Rodel, S.-H. Hwa, S. Cele, Y. Ganga, H. Tegally, M. Bernstein, J. Giandhari, COMMIT-KZN Team, B. I. Gosnell, K. Khan, W. Hanekom, F. Karim, T. de Oliveira, M.-Y. S. Moosa, A. Sigal
This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.
bioRxiv · Jun 1, 2021 · PreprintMicrobiology
J. Hunter, S. Cele, L. Jackson, J. Giandhari, T. de Oliveira, G. Lustig, A. Sigal
This study shows that HIV cell-free infection accelerates the evolution of drug resistance compared to cell-to-cell spread, with cell-free infection enabling multidrug resistance in the presence of two reverse transcriptase inhibitors.
bioRxiv · Sep 4, 2020 · PreprintEvolutionary Biology
L. Jackson, S. Cele, G. Lustig, J. Giandhari, T. de Oliveira, R. Neher, A. Sigal
The paper shows that complementation between drug-sensitive and resistant HIV genotypes maintains a stable quasispecies, preventing the resistant genotype from outcompeting the sensitive one.
bioRxiv · Apr 20, 2020 · PreprintEvolutionary Biology
G. Lustig, S. Cele, F. Karim, Y. Ganga, K. Khan, B. Gosnell, Y. Moosa, R. Harrichandparsad, S. Marais, R. Gupta, A. Derache, J. Giandhari, T. de Oliveira, K. Govender, J. Adamson, , A. Sigal
The paper investigates the origin of HIV in the CNS of ART-suppressed individuals and finds T cell-derived HIV that can lead to drug resistance.
bioRxiv · Mar 25, 2019 · PreprintMicrobiology