R. van Raaphorst

Rewiring capsule production by CRISPRi-based genetic oscillators demonstrates a functional role of phenotypic variation in pneumococcal-host interactions

This study uses CRISPRi-based oscillators to show that capsule production variation benefits pneumococcal pathogenesis.

Modulation of prey size reveals adaptability and robustness in the cell cycle of an intracellular predator

This study shows that prey size affects the cell cycle of Bdellovibrio bacteriovorus, determining offspring number, while prey quality influences growth rate independently of size.

Spatio-temporal control of DNA replication by the pneumococcal cell cycle regulator CcrZ

This study identifies CcrZ as a regulator that couples DNA replication with cell division in pneumococci by controlling DnaA activity, ensuring proper chromosome inheritance.

Chromosome dynamics and spatial organization during the non-binary cell cycle of a predatory bacterium

This study investigates chromosome dynamics and spatial organization in Bdellovibrio bacteriovorus during non-binary cell cycles, revealing complex replication and segregation patterns.

Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events

This study investigates pneumococcal transformation at the single-cell level, showing that multiple chromosomal integration events occur through unbiased homeologous recombination, with transformation efficiency capped at ~50%.

BactMAP: an R package for integrating, analyzing and visualizing bacterial microscopy data

BactMAP is an R package that integrates and visualizes bacterial microscopy data, enabling custom analysis and comparison across different segmentation tools.

Chromosome segregation drives division site selection in Streptococcus pneumoniae

This study shows that chromosome segregation, not protein factors, determines division site selection in Streptococcus pneumoniae by linking DNA replication timing to FtsZ and MapZ positioning.