Author

A. D. Grossman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 12

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 11 Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 7 Approach:genetic perturbation / CRISPR· 4 Research Focus:gene regulatory network inference· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

M. E. Anderson· 3 shared M. M. Harden· 3 shared E. L. Bean· 2 shared J. L. Smith· 2 shared L. K. McLellan· 2 shared A. Eldar· 1 shared B.-M. Koo· 1 shared C. A. Gross· 1 shared

Activity by Year

2018-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersMicrobiology

M. E. Anderson

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12 papers

Recent·Most cited

Timing of integration into the chromosome is critical for the fitness of an integrative and conjugative element and its bacterial host

S. A. McKeithen-Mead, A. D. Grossman

This study shows that the timing of integration of an integrative and conjugative element (ICE) into a bacterial chromosome is critical for the fitness of both the ICE and its host, with premature integration causing host lethality and reduced ICE spread.

bioRxiv · Nov 14, 2022Microbiology

TnSmu1 is a functional integrative and conjugative element in Streptococcus mutans that when expressed causes growth arrest of host bacteria

L. K. McLellan, M. E. Anderson, A. D. Grossman

bioRxiv · Aug 23, 2022Microbiology

Activation of the integrative and conjugative element Tn916 causes growth arrest and death of host bacteria

E. L. Bean, L. K. McLellan, A. D. Grossman

This study shows that activation of the conjugative transposon Tn916 in Bacillus subtilis and Enterococcus faecalis leads to growth arrest and cell death.

bioRxiv · Apr 1, 2022Microbiology

Biology and engineering of integrative and conjugative elements: Construction and analyses of hybrid ICEs reveal element functions that affect species-specific efficiencies

E. L. Bean, C. Herman, A. D. Grossman

The paper constructs hybrid integrative and conjugative elements (ICEs) by combining modules from Tn916 and ICEBs1 to study their transfer efficiencies into different bacterial species.

bioRxiv · Dec 16, 2021Microbiology

Spatio-temporal control of DNA replication by the pneumococcal cell cycle regulator CcrZ

C. Gallay, S. Sanselicio, M. E. Anderson, Y. M. Soh, X. Liu, G. A. Stamsas, S. Pelliciari, R. van Raaphorst, J. Denereaz, M. Kjos, H. Murray, S. Gruber, A. D. Grossman, J.-W. Veening

This study identifies CcrZ as a regulator that couples DNA replication with cell division in pneumococci by controlling DnaA activity, ensuring proper chromosome inheritance.

bioRxiv · Jun 2, 2021Microbiology

Multiple mechanisms for overcoming lethal over-initiation of DNA replication

M. E. Anderson, J. L. Smith, A. D. Grossman

The paper identifies multiple mechanisms by which cells regulate DNA replication in Bacillus subtilis, including reducing initiation and enhancing elongation to overcome over-initiation caused by dnaA1 mutation.

bioRxiv · May 6, 2021Microbiology

Beneficial and detrimental genes in the cellular response to replication arrest

L. Schons-Fonseca, M. D. Lazova, J. L. Smith, A. D. Grossman

This study identifies genes affecting survival during replication arrest in B. subtilis, finding that RecJ promotes cell death while AddA supports survival through RecA assembly differences.

bioRxiv · May 5, 2021Microbiology

A CRISPR interference screen reveals a role for cell wall teichoic acids in conjugation in Bacillus subtilis

M. M. Harden, A. D. Grossman

bioRxiv · May 4, 2021Microbiology

Specificity and selective advantage of an exclusion system in the integrative and conjugative element ICEBs1 of Bacillus subtilis

K. P. Davis, A. D. Grossman

The paper identifies regions in YddJ and ConG that confer exclusion specificity in ICEBs1 of Bacillus subtilis and shows exclusion protects donors from cell death during conjugation.

bioRxiv · Jan 25, 2021Microbiology

An integrative and conjugative element encodes an abortive infection system to protect host cells from predation by a bacteriophage

C. M. Johnson, M. M. Harden, A. D. Grossman

The paper identifies an abortive infection system encoded by an integrative and conjugative element (ICEBs1) that protects Bacillus subtilis from phage predation.

bioRxiv · Dec 13, 2020 · PreprintMicrobiology

A mobile genetic element increases bacterial host fitness by manipulating development

J. M. Jones, I. Grinberg, A. Eldar, A. D. Grossman

This study shows that the mobile genetic element ICEBs1 enhances bacterial host fitness by manipulating development during biofilm formation and sporulation.

bioRxiv · Oct 9, 2020Microbiology

Mobile-CRISPRi: Enabling Genetic Analysis of Diverse Bacteria

J. M. Peters, B.-M. Koo, R. Patino, G. E. Heussler, C. C. Hearne, Y. Inclan, J. S. Hawkins, C. H. S. Lu, M. M. Harden, H. Osadnik, J. E. Peters, J. N. Engel, R. J. Dutton, A. D. Grossman, C. A. Gross, O. S. Rosenberg

The paper introduces Mobile-CRISPRi, a CRISPRi system for non-model bacteria, demonstrating its use in analyzing gene function and antibiotic resistance in human pathogens.

bioRxiv · May 5, 2018Microbiology