Author

R.-T. Guo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

C.-C. Chen· 2 shared J. Xue· 2 shared X. Li· 2 shared Y. Yang· 2 shared Y. Zhang· 2 shared E. Oldfield· 1 shared H. Xiao· 1 shared H. Yang· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

C.-C. Chen

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Author profile →

2 papers

Recent·Most cited

Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation

L. Yuan, X. Ma, Y. Yang, X. Li, W. Ma, H. Yang, J.-W. Huang, J. Xue, S. Yi, M. Zhang, N. Cai, Q. Ding, L. Li, J. Duan, S. Malwal, , Y. Zhang

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

bioRxiv · Jan 2, 2022 · PreprintImmunology

KRAS G12D can be targeted by potent salt-bridge forming inhibitors

Z. Mao, H. Xiao, P. Shen, Y. Yang, J. Xue, Y. Yang, Y. Shang, L. Zhang, X. Li, Y. Zhang, Y. Du, C.-C. Chen, R.-T. Guo, Y. Zhang

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

bioRxiv · Dec 13, 2021 · PreprintCancer Biology