L. Yuan

An interpretable integration model improving disease-free survival prediction for gastric cancer based on CT images and clinical parameters

This paper proposes a model integrating deep features, radiomics features, and clinical parameters to improve gastric cancer disease-free survival prediction, achieving a 3%-5% C-index and 10% AUC improvement.

Global RNA Virome in Wastewater Treatment Plants Reveals Ecological Insights and Human Health Implications

This study analyzes RNA virus diversity in wastewater treatment plants, identifying new viral lineages and their ecological and health implications.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

EI24-RTRAF interaction represses Nox4 translation, vital for redox balance and insulin production

The paper identifies EI24-RTRAF interaction as a regulator of Nox4 translation, maintaining redox balance and insulin production in pancreatic beta cells.

Regulation of lactose and galactose growth: Insights from a unique metabolic gene cluster in Candida intermedia

This study identifies three gene clusters in Candida intermedia responsible for lactose and galactose metabolism, revealing a unique regulatory network distinct from other yeasts.

The change of lymphocyte subsets and inflammatory cytokine in BK viruria

This study compares cytokine levels in urine and blood of kidney transplant recipients with and without BK viruria, finding higher inflammatory cytokines in BK-positive patients.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

Hsa_circ_0005397 could promote hepatocellular carcinoma progression and metastasis through EIF4A3

This study identifies hsa_circ_0005397 as a promoter of hepatocellular carcinoma progression and metastasis via EIF4A3, showing its diagnostic and prognostic significance.

Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial

The paper develops a spatial quantitative systems pharmacology model for virtual clinical trials in HCC, validated with spatial multi-omics data from a neoadjuvant immunotherapy trial.

Butyrate Protects against SARS-CoV-2-induced Tissue Damage in Golden Hamsters.

This study shows butyrate protects against SARS-CoV-2-induced tissue damage in golden hamsters by enhancing antiviral immunity and reducing oxidative stress.

Complex epistatic interactions between ELF3, PRR9, and PRR7 regulates the circadian clock and plant physiology

The paper investigates the genetic interactions between ELF3, PRR9, and PRR7 in Arabidopsis, revealing complex epistatic relationships affecting circadian rhythms and plant development.

Nanobodies against SARS-CoV-2 reduced virus load in the brain of challenged mice and neutralized Wuhan, Delta and Omicron Variants

This study develops nanobodies against SARS-CoV-2 that neutralize multiple variants and reduce viral load in the brain of infected mice.

Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

This study uses spatial transcriptomics to analyze HCC tumors treated with cabozantinib and nivolumab, identifying distinct immune and fibrotic mechanisms linked to response and recurrence.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

The direct interaction with transcriptional factor TEAD4 implied a straightforward regulation mechanism of tumor suppressor NF2

This study identifies a direct interaction between NF2 and TEAD4, showing NF2 inhibits TEAD4 stability and function, revealing a new mechanism of NF2's tumor suppressor role via the Hippo pathway.

Soft and stretchable organic bioelectronics for continuous intra-operative neurophysiological monitoring during microsurgery

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

This study identifies that TRPV1 drugs alter core body temperature through central projections of sensory neurons, not peripheral vascular effects.

Cellular dynamics of endosperm development in Arabidopsis thaliana

The paper characterizes the cellular dynamics of coenocytic endosperm development in Arabidopsis thaliana using live-cell imaging and genetics, revealing roles of cytoskeleton components in nuclear movement and seed size control.

An interactive viral genome evolution network analysis system enabling rapid large-scale molecular tracing of SARS-CoV-2

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

Fracture healing is delayed in the absence of gasdermin signaling

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

A live attenuated influenza virus-vectored intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2 infection

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

ICER controls HIV-1 infection and replication in elite controllers

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

Using mixed-effects modeling to estimate decay kinetics of response to SARS-CoV-2 infection

This study reanalyzes SARS-CoV-2 immunity data using mixed-effects modeling, finding longer and more variable half-lives than previously reported.

Sterilizing immunity against SARS-CoV-2 in hamsters conferred by a novel recombinant subunit vaccine

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

Pathogenic and Indigenous Denitrifying Bacteria are Transcriptionally Active and Key Multi-Antibiotic Resistant Players in Wastewater Treatment Plants

The paper analyzes ARG hosts in WWTPs using metatranscriptomics, finding 45% of genomes express multi-antibiotic resistance genes, with pathogens and denitrifying bacteria as key hosts.

Virus-free and live-cell visualizing SARS-CoV-2 cell entry for studies of neutralizing antibodies and compound inhibitors

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.