Yann Loe-Mie

The paper tracks viral infection in Ostreococcus tauri, showing pre-existing genome architecture dictates viral positioning and transcriptional changes during infection.

The paper uses single-cell and spatial transcriptomics to study hematopoietic stem and progenitor cell diversity and their niches in zebrafish development.

The paper investigates outlier chromosomes in marine picoeukaryotes, revealing their structural insulation and dynamic nature through 3D genome organization analysis.

The paper shows that Z-DNA formation promotes totipotent-like state and primes Zscan4-dependent chromatin compartmentalization during early mouse development.

The paper investigates AUTS2 expression across mammalian species to identify phenotypes linked to Autism Spectrum Disorders.

This study shows that AUTS2 gene dosage affects synaptic AMPA receptors through the AUTS2-TTC3-AKT-mTORC1 pathway, leading to behavioral and cognitive impairments in mice.

This study uses TATTOO-seq to identify spatial and cell type-specific regulatory programs during limb development and shows how perturbations affect cell fate and spatial organization.

This paper shows that BIN1 overexpression in mice leads to early structural and functional impairments in hippocampal pathways associated with Alzheimer's disease, independent of A-beta changes.

The paper introduces instaGRAAL, a Hi-C-based scaffolder that improves chromosome-level genome assemblies for brown algae.

The paper identifies protein-protein interactions on Chr21 linked to intellectual disabilities, autism, and Alzheimer's by analyzing yeast two-hybrid screens and synaptic localization.

The paper identifies a multi-hit genomic architecture for ASD in consanguineous families, involving FEZF2 deletions and mutations in high-risk genes.

The paper uses whole-organism single-cell RNA-seq to analyze cell type diversity in Nematostella vectensis, identifying 35% of genes and 51% of TFs as cell type-specific.

This study shows that cohesin removal leads to loss of TADs and loops but preserves compartments, revealing two independent modes of chromosome organization.