Author

Eugene Y. Yu

Roswell Park Comprehensive Cancer CenterORCID 0000-0002-8152-0790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Yann HéraultiD· 2 shared Anne BolandiD· 1 shared Antigoni ManousopoulouiD· 1 shared Aude-Marie Lepagnol-BesteliD· 1 shared Christine PlançoniD· 1 shared Clotilde MircheriD· 1 shared Eleni GkanatsiouiD· 1 shared Elizabeth FisheriD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Yann HéraultORCID

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3 papers

Recent·Most cited

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21

Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou, Gloria Lau, Suzanna Noy, Karen Cleverley, Takashi Saito, Takaomi C. Saido, Eugene Y. Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor L. J. Tybulewicz, , Frances K. Wiseman

This study identifies chromosome 21 genes other than APP that modulate amyloid-β accumulation in Down syndrome mouse models.

Journal of Neuroscience · Jul 14, 2022Peer-reviewedNeuroscience

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome

Véronique Brault, Thu Lan Nguyen, Javier Flores Gutiérrez, Giovanni Lo Iacono, Marie‐Christine Birling, Valérie Lalanne, Hamid Méziane, Antigoni Manousopoulou, Guillaume Pavlovic, Loïc Lindner, Mohammed Selloum, Tania Sorg, Eugene Y. Yu, Spiros D. Garbis, Yann Hérault

This study investigates the effects of Dyrk1a gene dosage in glutamatergic neurons on cognitive deficits in MRD7 and Down syndrome mouse models, finding specific roles in long-term explicit memory.

PLoS Genetics · Sep 29, 2021Peer-reviewedNeuroscience

Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plançon, Anne Boland, Francisco J. Tejedor, Richard L. Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Y. Yu, Valérie Hindie, , Aude-Marie Lepagnol-Bestel

The paper identifies protein-protein interactions on Chr21 linked to intellectual disabilities, autism, and Alzheimer's by analyzing yeast two-hybrid screens and synaptic localization.

bioRxiv · Dec 11, 2019 · PreprintNeuroscience