Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesis
Chloé S. Baron, Olivia Mitchell, Serine Avagyan, Romain Menard, Song P. Yang, Anne L. Robertson, Rajiv Potluri, Jay Shendure, Romain Madelaine, Aaron McKenna, Leonard Ira Zon
The paper shows that leukemia cells secrete apelin, which promotes clonal expansion of niche endothelial cells and drives leukemogenesis in zebrafish.
bioRxiv · Sep 9, 2024 · PreprintCancer Biology