Romain Madelaine

Mesenchymal-derived neural progenitors underlie local insulin production and neuronal transdifferentiation during retina regeneration

This study identifies mesenchymal-derived neural progenitors that transdifferentiate into retinal ganglion cells in zebrafish after neuronal ablation, revealing a novel mechanism for retinal regeneration.

Sexually Dimorphic Response to Dietary Restriction-induced Longevity and Muscle Rejuvenation in Nothobranchius furzeri.

This study shows that intermittent fasting improves muscle health and extends lifespan in both sexes of African turquoise killifish, with sex-specific molecular and cellular changes.

Zebrafish genetic model of neuromuscular degeneration associated with Atrogin-1 expression

The paper develops a zebrafish model of accelerated muscle atrophy by inducing Atrogin-1 expression, showing muscle degeneration, locomotion dysfunction, and neurodegenerative effects.

The small molecule ML233 is a direct inhibitor of tyrosinase function

This study identifies ML233 as a potent and safe tyrosinase inhibitor that reduces melanin production in zebrafish and murine melanoma cells without significant toxicity.

Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesis

The paper shows that leukemia cells secrete apelin, which promotes clonal expansion of niche endothelial cells and drives leukemogenesis in zebrafish.

Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development

The paper shows Neurog1 controls olfactory organ morphogenesis through cxcr4b in zebrafish.

Cell-type heterogeneity in the zebrafish olfactory placode is generated from progenitors within preplacodal ectoderm

The paper shows that Gnrh3 and microvillous sensory neurons in zebrafish olfactory placodes originate from preplacodal ectoderm progenitors, not cranial neural crest.