The paper shows that leukemia cells secrete apelin, which promotes clonal expansion of niche endothelial cells and drives leukemogenesis in zebrafish.

bioRxiv · Sep 9, 2024 · PreprintCancer Biology

A molecular switch: Ro5-3335 drives hematopoietic stem cell division and clonality through distinct RUNX1 binding partners

Anne L. Robertson, Yue Lü, Avik Choudhuri, Daniel Fernández-Pérez, Alex Maya Pombo, Caroline Kubaczka, Samuel J. Wattrus, Kyle D. Drake, Joseph Mandelbaum, Serine Avagyan, Song P. Yang, Rohan Bhattacharya, Rebecca J. Freeman, Victoria Chan, Megan C. Blair, , Leonard Ira Zon

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

bioRxiv · Jun 7, 2024 · PreprintCell Biology

Transcription factors interact with RNA to regulate genes

Ozgur Oksuz, Jonathan E. Henninger, Robert Warneford-Thomson, Ming Zheng, Hailey Erb, Adrienne Vancura, Kalon J. Overholt, Susana Wilson Hawken, Salman F. Banani, Richard Lauman, Lauren N. Reich, Anne L. Robertson, Nancy M. Hannett, Tong Ihn Lee, Leonard Ira Zon, , Richard A. Young

The paper identifies RNA-binding as a common feature of transcription factors, showing it contributes to gene regulation and is conserved in vertebrates.

Molecular Cell · Jul 1, 2023Peer-reviewedMolecular Biology

Specific Oxylipins Enhance Vertebrate Hematopoiesis via the Receptor GPR132

Jamie L. Lahvic, Michelle Ammerman, Pulin Li, Megan C. Blair, Emma Stillman, Eva Maria Fast, Anne L. Robertson, Constantina Christodoulou, Julie R. Perlin, Song P. Yang, Nan Chiang, Paul C. Norris, Madeleine L. Daily, Shelby E. Redfield, Iris T. Chan, , Leonard Ira Zon

The paper identifies GPR132 as a specific receptor for certain oxylipins that enhance hematopoiesis in vertebrates, using bioinformatics and functional assays.

Proceedings of the National Academy of Sciences · Aug 23, 2018Peer-reviewedDevelopmental Biology