ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy
Randolph M. Johnson, Songnan Wang, Jacqueline A. Carozza, Daniel Fernández, Jan J. Scicinski, Neil A. Verity, Rachel E. Mardjuki, Xujun Cao, Jacqueline S. Papkoff, Nigel Ray, Lingyin Li
A small molecule blocks ENPP1, reviving immune attack on tumors and enhancing immune therapy with minimal side effects in preclinical cancer models.
bioRxiv · May 18, 2025 · PreprintCancer Biology