Author

Songnan Wang

Arc Research InstituteORCID 0000-0002-4276-2965Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Jacqueline A. CarozzaiD· 2 shared Lingyin LiiD· 2 shared Daniel FernándeziD· 1 shared Gabriel Grenot· 1 shared Gemini M. Skariah· 1 shared J. Michelle Lee· 1 shared Jacqueline S. Papkoff· 1 shared Jan J. Scicinski· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Jacqueline A. CarozzaORCID

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2 papers

Recent·Most cited

ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance

Songnan Wang, Yingjie Guo, Weidong An, J. Michelle Lee, Yu Li, Valentino Sudaryo, Jacqueline A. Carozza, Gabriel Grenot, Gemini M. Skariah, Saranya Chidambaranathan Reghupaty, Sonny Young, Xiaochen Bai, Katrin J. Svensson, Lingyin Li

This study shows that the ENPP1 K173Q variant reduces cGAMP hydrolysis, leading to increased extracellular cGAMP and insulin resistance in brown adipose tissue.

Cell Reports · Sep 15, 2026Peer-reviewedImmunology

ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy

Randolph M. Johnson, Songnan Wang, Jacqueline A. Carozza, Daniel Fernández, Jan J. Scicinski, Neil A. Verity, Rachel E. Mardjuki, Xujun Cao, Jacqueline S. Papkoff, Nigel Ray, Lingyin Li

A small molecule blocks ENPP1, reviving immune attack on tumors and enhancing immune therapy with minimal side effects in preclinical cancer models.

bioRxiv · May 18, 2025 · PreprintCancer Biology