Jacqueline A. Carozza

This study shows that the ENPP1 K173Q variant reduces cGAMP hydrolysis, leading to increased extracellular cGAMP and insulin resistance in brown adipose tissue.

This study evaluates an imperfect prophylactic treatment for chytridiomycosis in amphibians, finding that it unexpectedly increased infection intensity in treated ponds.

The paper identifies SLC7A1 as the transporter for cGAMP and its analogs in T cells, showing that targeting this transporter can reduce toxicity without affecting arginine transport.

A small molecule blocks ENPP1, reviving immune attack on tumors and enhancing immune therapy with minimal side effects in preclinical cancer models.

The paper identifies ENPP3 as a second cGAMP hydrolase, showing it regulates cGAMP levels and impacts cancer immunity.