Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interaction networks
Scott W. Simpkins, Justin Nelson, Raamesh Deshpande, Sheena Claire Li, Jeff S. Piotrowski, Erin H. Wilson, Abraham Abera Gebre, Hamid Safizadeh, Reika Okamoto, Mami Yoshimura, Michael Costanzo, Yoko Yashiroda, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, , Chad L. Myers
The paper develops CG-TARGET to predict compound biological processes by integrating chemical-genetic and genetic interaction networks, showing improved accuracy and FDR control.
PLoS Computational Biology · Oct 30, 2018Peer-reviewedSystems Biology