Raamesh Deshpande

Comparing host module activation patterns and temporal dynamics in infection by influenza H1N1 viruses

This study compares host module activation patterns and temporal dynamics across four influenza H1N1 viruses to identify conserved and differentially regulated immune responses.

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interaction networks

The paper develops CG-TARGET to predict compound biological processes by integrating chemical-genetic and genetic interaction networks, showing improved accuracy and FDR control.

Functional Annotation of Chemical Libraries across Diverse Biological Processes

This study develops a yeast-based chemical-genetic screening system to annotate compound functionality across biological processes and identifies compounds with dual modes of action.

Efficient strategies for screening large-scale genetic interaction networks

The paper introduces COMPRESS-GI, an algorithm that efficiently selects informative genes for genetic interaction screens, enabling large-scale chemical genetic screens with high throughput.

Systematic identification of pleiotropic genes from genetic interactions

The paper measures pleiotropy in yeast genes using genetic interaction networks, finding high-pleiotropy genes have broader functional influence and distinct characteristics compared to low-pleiotropy genes.