Constitutive cGAS-STING activation in ALT+ cells
Dan Geelen, Alexander Beacom, Mélina Vaurs, Manon Mahieu, Rachid Boutoual, Amélie Derumier, Remington E. Hoerr, Axelle E. Loriot, Joe Nassour, Anabelle Decottignies
The paper reveals how ALT+ cells sustain cGAS-STING activation through spatial regulation and lysosomal degradation of STING and ECTR species, suggesting therapeutic targets for ALT+ tumors.
bioRxiv · Apr 18, 2025 · PreprintCell Biology