Oncogenic ETS factors expressed from fusion genes utilize EWSR1 to associate with the paraspeckle and regulate transcription.
Renee A. Kinne, Peter C. Hollenhorst
This study shows that EWSR1 from fusion genes interacts with paraspeckles to regulate transcription in cancers, and disrupting paraspeckles mimics loss of oncogenic ETS factors.
bioRxiv · Oct 14, 2026 · PreprintCancer Biology