Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

bioRxiv · Oct 13, 2026 · PreprintCancer Biology✦ In-depth digest

Activation of vitamin D signaling suppresses platinum-induced ovarian cancer stem cell plasticity

Tara X. Metcalfe, Sophie Xanders, Renee A. Kinne, Saranya Rajendran, Shu Zhang, Peter C. Hollenhorst, Alexandre Gaspar‐Maia, Heather M. O’Hagan, Kenneth P. Nephew

This study shows that vitamin D signaling activation suppresses platinum-induced ovarian cancer stem cell plasticity, reducing stemness and tumor growth in vivo.

bioRxiv · Sep 23, 2026 · PreprintCancer Biology

Blood Based Biomarkers of DNA Methylation Associated with Platinum Resistance in High Grade Serous Ovarian Cancer

Elnaz Abbasi Farid, Shu Zhang, Horacio Cárdenas, Zhen Fu, Adam Vieth, Collin M. Coon, Jian‐Jun Wei, Daniela Elena Matei, Kenneth P. Nephew

bioRxiv · Apr 24, 2026 · PreprintGenomics

Effects of the Hypomethylating Agent Guadecitabine on Peripheral Blood Mononuclear Cell Methylomes and Immune Cell Populations in Small-Cell Lung Cancer Patients

Elnaz Abbasi Farid, Shu Zhang, Zhen Fu, Collin M. Coon, Daniela Elena Matei, Shadia Ibrahim Jalal, Kenneth P. Nephew

This study examines methylome changes and immune cell shifts in SCLC patients treated with guadecitabine, revealing hypomethylation and altered immune profiles.

Pharmaceuticals · Mar 28, 2026Peer-reviewedGenomics