Heather M. O’Hagan

Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

This study shows that vitamin D signaling activation suppresses platinum-induced ovarian cancer stem cell plasticity, reducing stemness and tumor growth in vivo.

This study shows mast cells promote epithelial-to-mesenchymal transition in colorectal cancer through direct contact and integrin-mediated signaling.

This study shows that LSD1 inhibition reduces lineage plasticity caused by BRAF and EGFR inhibitors in BRAFV600E colorectal cancer.

The paper uses single-cell multi-omics to study EEC differentiation in mucinous colorectal cancer, identifies STAT3 as a regulator, and discovers a rare cancer cell type with neuron-like features.

This study shows that goblet cell content influences CMS3 subtype classification in colorectal cancer using machine learning.