Author

Tara X. Metcalfe

Indiana University BloomingtonORCID 0000-0003-2074-9484Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Heather M. O’HaganiD· 2 shared Kenneth P. NephewiD· 2 shared Shu ZhangiD· 2 shared Alexandre Gaspar‐MaiaiD· 1 shared Benjamin Guy BitleriD· 1 shared Lindsay W Brubaker· 1 shared Peter C. HollenhorstiD· 1 shared Renee A. Kinne· 1 shared

Activity by Year

2026-2026 · peak 2/yr

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10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Heather M. O’HaganORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 13, 2026

✦ In-depth digest

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

Shu Zhang, Zhen Fu, Yanchi Zhou…·Kenneth P. Nephew

Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

DOI 10.64898/2026.09.22.753550

humanmouse

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Cancer BiologybioRxivPreprintSep 23, 2026

Activation of vitamin D signaling suppresses platinum-induced ovarian cancer stem cell plasticity

Tara X. Metcalfe, Sophie Xanders, Renee A. Kinne…·Kenneth P. Nephew

This study shows that vitamin D signaling activation suppresses platinum-induced ovarian cancer stem cell plasticity, reducing stemness and tumor growth in vivo.

DOI 10.64898/2026.09.22.753468

humanbulk RNA-seq

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