Author

Renuka Sivapatham

Buck Institute for Research on Aging

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Systems Biology· 1

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Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metabolomics· 1

Frequent Co-Authors

Angelina HolcomiD· 1 shared Anna FoulgeriD· 1 shared Birgit SchillingiD· 1 shared Christina D. KingiD· 1 shared David FurmaniD· 1 shared Dipa Bhaumik· 1 shared Gordon J. LithgowiD· 1 shared Hadley Osman· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperSystems Biology

Angelina HolcomORCID

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1 paper

Recent·Most cited

Neuronal expression of human amyloid-β and Tau drives global phenotypic and multi-omic changes in C. elegans

Angelina Holcom, Matías Fuentealba, Renuka Sivapatham, Christina D. King, Hadley Osman, Anna Foulger, Dipa Bhaumik, Birgit Schilling, David Furman, Julie Kay Andersen, Gordon J. Lithgow

This study shows that expressing human amyloid-β and Tau in C. elegans neurons causes phenotypic and multi-omic changes, including accelerated aging and metabolic dysfunction.

bioRxiv · Jun 1, 2023 · PreprintSystems Biology