Systems BiologybioRxivPreprint
Neuronal expression of human amyloid-β and Tau drives global phenotypic and multi-omic changes in C. elegans
Angelina Holcom, Matías Fuentealba, Renuka Sivapatham…·Gordon J. Lithgow
This study shows that expressing human amyloid-β and Tau in C. elegans neurons causes phenotypic and multi-omic changes, including accelerated aging and metabolic dysfunction.
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