Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation
María Rosaria Pricolo, Miguel Ángel López-Unzu, Natalia Vicente, Cristina Morales-Lopez, Carla Huerta-López, Wendy Perez-Franco, Andra C. Dumitru, Jorge Peña-Peña, Francisco M. Espinosa, Mateo I. Sanchez, Ricardo Garcia, Roberto Silva‐Rojas, Miguel Torres, Elías Herrero‐Galán, Jorge Alegre‐Cebollada
This study shows that inducing sarcomere disassembly in cardiomyocytes via titin cleavage does not lead to cell proliferation, suggesting additional factors are needed for cardiomyocyte division.
Journal of Biological Chemistry · May 15, 2026Peer-reviewedCell Biology