Author

Jorge Peña-Peña

Spanish National Centre for Cardiovascular ResearchORCID 0000-0002-9754-0497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Miguel TorresiD· 2 shared Agnieszka PiszczekiD· 1 shared Andra C. DumitruiD· 1 shared Carla Huerta-LópeziD· 1 shared Cristina Morales-Lopez· 1 shared Elad BassatiD· 1 shared Elías Herrero‐GalániD· 1 shared Elly Margaret TanakaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Miguel TorresORCID

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2 papers

Recent·Most cited

Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation

María Rosaria Pricolo, Miguel Ángel López-Unzu, Natalia Vicente, Cristina Morales-Lopez, Carla Huerta-López, Wendy Perez-Franco, Andra C. Dumitru, Jorge Peña-Peña, Francisco M. Espinosa, Mateo I. Sanchez, Ricardo Garcia, Roberto Silva‐Rojas, Miguel Torres, Elías Herrero‐Galán, Jorge Alegre‐Cebollada

This study shows that inducing sarcomere disassembly in cardiomyocytes via titin cleavage does not lead to cell proliferation, suggesting additional factors are needed for cardiomyocyte division.

Journal of Biological Chemistry · May 15, 2026Peer-reviewedCell Biology

AXL governs axolotl cardiac regeneration and directs mammalian cardiomyocyte dedifferentiation

Elad Bassat, Jingkui Wang, Jorge Peña-Peña, Inés Rivero-García, Agnieszka Piszczek, Francisco Falcon, Yuka Taniguchi‐Sugiura, Jiaye Yang, Paula Fernández-Montes, Thomas Lendl, Lorena Domínguez, Katharina Lust, José Antonio Enríquez, Fátima Sánchez‐Cabo, Miguel Torres, Elly Margaret Tanaka

This study identifies AXL as a key regulator of cardiac regeneration in axolotls and shows its role in inducing cardiomyocyte dedifferentiation in mammals without cell cycle re-entry.

bioRxiv · Dec 22, 2025 · PreprintCell Biology