Miguel Torres

The paper develops a computational workflow to analyze tissue deformation in mouse heart tube formation, revealing compartmentalized deformation patterns and a new model of heart morphogenesis.

This study shows that inducing sarcomere disassembly in cardiomyocytes via titin cleavage does not lead to cell proliferation, suggesting additional factors are needed for cardiomyocyte division.

The paper identifies 3D regulatory hubs involved in sex determination using spatial auto-correlation analysis in mouse embryos.

The paper identifies molecular differences between regenerating blastema and non-regenerating CSD in axolotl limbs and uses Wnt3a expression to induce cartilage bridging in CSD.

This study identifies AXL as a key regulator of cardiac regeneration in axolotls and shows its role in inducing cardiomyocyte dedifferentiation in mammals without cell cycle re-entry.

This paper develops a method to analyze tissue motion and deformation during mammalian organogenesis using live imaging data of heart development.

The paper shows that MEIS2 and DLX5 activate enhancers for projection neurons, while LHX6 represses them in interneurons, and a MEIS2 mutation linked to intellectual disability impairs this process.

SpatialDDLS deconvolutes spatial transcriptomics data using neural networks, showing accuracy and speed compared to existing methods.

The paper identifies epigenetic priming of lineage-specific fates in the mammalian epiblast, revealing early specification of endothelial and mesodermal lineages.

The paper identifies P53 and its targets PUMA and NOXA as regulators of competitive fitness in pluripotent cells through mitochondrial regulation.

This study identifies VEGFC and VEGFD as essential mediators of coronary lymphangiogenesis, with a sex-specific role for VEGFD in females.

The paper provides a complete morphological description of heart tube formation in mice, identifying regional variability and early left-right asymmetry.

This study identifies a feedback loop between Meis transcription factors and retinoic acid in regulating axial skeleton patterning in mice.

The paper shows Myc is not essential for cardiac development in mice but can replace Mycn function in its absence through cell competition.

The paper uses live imaging of mouse embryos to show that heart tube development involves alternating phases of cardiac differentiation and morphogenesis.