Author

Brendan C. McIntyre

Children's Hospital of PhiladelphiaORCID 0000-0002-6473-5140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Chunlong ZhaoiD· 1 shared Courtney HimsworthiD· 1 shared Elisavet Kalaitsidou· 1 shared Frank J. DekkeriD· 1 shared Grant P. GrothuseniD· 1 shared Guillem Pascual‐PastoiD· 1 shared Henrike P. MulleriD· 1 shared Jan J. MolenaariD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Chunlong ZhaoORCID

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1 paper

Recent·Most cited

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

Josephine G. M. Strijker, Guillem Pascual‐Pasto, Grant P. Grothusen, Yannine J. Kalmeijer, Elisavet Kalaitsidou, Chunlong Zhao, Brendan C. McIntyre, Stephanie Matlaga, Lindy L. Visser, Marta Barisa, Courtney Himsworth, Rivani Shah, Henrike P. Muller, Linda G. Schild, Peter G. Hains, , Judith Wienke

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

European Journal of Cancer · Jan 27, 2025Peer-reviewedCancer Biology