β-hydroxybutyrate improves convulsions in mice carrying the GRIN1 Y647S/+ pathogenic variant
Megan T. Sullivan, Patrick Tidball, Yuanye Yan, Katheron Intson, Wenjuan Chen, Yuchen Xu, Sridevi Venkatesan, Wendy Horsfall, John Georgiou, Peter S.B. Finnie, Robert E. McCullumsmith, Evelyn K. Lambe, Stephen F. Traynelis, Ali Salahpour, Hongjie Yuan, , Amy J. Ramsey
This study investigates the effects of the GRIN1 Y647S variant in mice, showing that β-hydroxybutyrate reduces convulsions associated with the variant.
bioRxiv · Aug 21, 2024 · PreprintNeuroscience