Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network development in vivo
Jürgen Graf, Chuanqiang Zhang, Stephan Lawrence Marguet, Tanja Herrmann, Tom Floßmann, Robin Hinsch, Vahid Rahmati, Madlen Guenther, Christiane Frahm, Anja Urbach, Ricardo M. Neves, Otto Wilhelm Witte, Stefan J. Kiebel, Dirk Isbrandt, Christian Andreas Hübner, , Knut Kirmse
This study shows that NKCC1 deletion in developing mice has minimal impact on hippocampal network development and behavior, challenging its essential role in these processes.
Proceedings of the National Academy of Sciences · Mar 29, 2021Peer-reviewedNeuroscience