Knut Holthoff

Spontaneous network activity links misrouted interneuron migration to cortical maturation abnormalities

This study shows that disrupted migration of inhibitory neurons leads to persistent functional deficits in cortical networks, linking migratory guidance to circuit integrity.

Anti-NMDAR encephalitis alters intrinsic spatiotemporal coding by enhancing neuronal coupling and clustering

This study investigates how anti-NMDAR encephalitis alters neuronal network function by enhancing coupling and clustering in hippocampal neurons during slow-wave sleep.

The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11

This study shows that NKCC1 regulates hippocampal neural stem cell self-renewal via Sox11, with reduced NKCC1 in aging promoting symmetric division and decreased neurogenesis.

Harnessing early multimodal motor training to drive motor recovery and brain-wide structural reorganization after stroke

This study shows that early multimodal motor training after stroke improves motor function and causes widespread brain structural changes in rats.

A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration

The paper shows that tactile stimulation suppresses visual activity in primary visual cortex via interneurons receiving input from somatosensory cortex in mice.

Chemogenetic silencing reveals presynaptic Gi/o protein-mediated inhibition of synchronized activity in the developing hippocampus in vivo

This study uses Gi-DREADDs to show that presynaptic inhibition of glutamatergic neurotransmission in neonatal hippocampal neurons suppresses synchronized network activity.

Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo

The paper identifies network instability dynamics as a driver of transient bursting activity in the developing hippocampus, revealing a mechanism for input-discrimination learning before environmental exploration.

Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network development in vivo

This study shows that NKCC1 deletion in developing mice has minimal impact on hippocampal network development and behavior, challenging its essential role in these processes.