Otto Wilhelm Witte

This study uses multi-omics and metabolic modeling in mice to show that aging reduces host-microbiome metabolic interactions, affecting key host pathways involved in intestinal barrier function and homeostasis.

This study shows that early multimodal motor training after stroke improves motor function and causes widespread brain structural changes in rats.

The paper shows that tactile stimulation suppresses visual activity in primary visual cortex via interneurons receiving input from somatosensory cortex in mice.

This study shows that adult hippocampal neural stem cells (aNSCs) form in the early postnatal dentate gyrus and require cyclin D2 for their development.

The paper identifies network instability dynamics as a driver of transient bursting activity in the developing hippocampus, revealing a mechanism for input-discrimination learning before environmental exploration.

A survey of the German neuroscience community identifies key barriers to reproducible research and outlines strategies for improving research data management.

The paper shows that exosomes from aged mice can cross the blood-brain barrier and activate glial cells, as indicated by increased GFAP expression.

This study shows that Cobl is essential for post-stroke dendritic arbor repair in mice, with its levels reduced by ischemic stroke but restored through increased mRNA expression.

This study shows that NKCC1 deletion in developing mice has minimal impact on hippocampal network development and behavior, challenging its essential role in these processes.

The paper shows that intense learning in rats leads to temporary increases in brain grey matter volume, associated with synaptic and astrocyte remodeling, and a return to baseline volume with persistent spine maturation.

This review summarizes how maternal stress and malnutrition during pregnancy affect structural brain aging and age-related brain disorders in humans.