Christiane Frahm

This study identifies nonlinear gene-expression trajectories in the aging male mouse colon, revealing midlife transitions and a transcriptomic clock based on three genes.

This study shows social isolation in aged mice increases inflammatory oxylipins in multiple organs but not serum, with exercise failing to reduce these effects.

The paper integrates multi-omics data from mice to identify molecular features linked to aging-related cognitive decline, highlighting systemic inflammation and microbiome-driven gut-brain axis dysfunction.

This study uses multi-omics and metabolic modeling in mice to show that aging reduces host-microbiome metabolic interactions, affecting key host pathways involved in intestinal barrier function and homeostasis.

This study shows that early multimodal motor training after stroke improves motor function and causes widespread brain structural changes in rats.

This study shows that Cobl is essential for post-stroke dendritic arbor repair in mice, with its levels reduced by ischemic stroke but restored through increased mRNA expression.

This study shows that NKCC1 deletion in developing mice has minimal impact on hippocampal network development and behavior, challenging its essential role in these processes.