ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restriction
Niklas L Kahler, Sefanit Rezene, Florine E. M. Scholte, Anoop T. Ambikan, Elisa Saccon, Vanessa Monteil, Prajakta Naval, Robin Macmillan, Simon Frick, Jenny Norén, Magda Lourda, Alì Mirazimi, Yenan T. Bryceson, Ronaldo Lira‐Junior, Vibhu Ranjan Prasad, , Soham Gupta
This study shows that ISG15-USP18 signaling limits viperin-dependent metabolic antiviral restriction by stabilizing USP18 and reducing viperin expression, thereby inhibiting viral replication.
bioRxiv · Mar 14, 2026 · PreprintMicrobiology