Anoop T. Ambikan

Integrated Clinical and Proteomic Precision Subgrouping for Severe Dengue Endotype Signature

The paper identifies molecular signatures and endotypes in severe dengue by integrating clinical and proteomic data, revealing immune pathways associated with severe disease.

Type I IFN reprograms CD4⁺ T cell lipid metabolism as an antiviral effector mechanism during acute HIV/SIV infection

The paper investigates how type I IFN reprograms CD4⁺ T cell lipid metabolism during acute HIV/SIV infection and identifies metabolic changes linked to viral reservoir establishment.

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19

This study identifies ISG expression endotypes in COVID-19 patients and links lipid metabolism to immune dysfunction in severe disease.

ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restriction

This study shows that ISG15-USP18 signaling limits viperin-dependent metabolic antiviral restriction by stabilizing USP18 and reducing viperin expression, thereby inhibiting viral replication.

Integrated Systems Vaccinology Reveals Distinct Metabolic Responses to SARS-CoV-2 Infection and DNA-Based Vaccines in Ferrets

This study uses metabolomics to compare metabolic responses to SARS-CoV-2 infection and different vaccines in ferrets, revealing distinct metabolic signatures linked to immune responses and vaccine efficacy.

Parechovirus-3 infection disrupts immunometabolism and leads to glutamate excitotoxicity in neural organoids

This study identifies metabolic changes and glutamate excitotoxicity in HPeV-3 infected neural organoids, linking them to neuronal toxicity and apoptosis.

Immune-Coagulation Dynamics in Severe COVID-19: Insights from Autoantibody Profiling and Transcriptomics

This study investigates immune-coagulation dynamics in severe COVID-19 by analyzing autoantibody profiles and transcriptomics, finding correlations between autoantibody reactivities and coagulation gene expression.

Altered Glycolysis TCA Anaplerosis Axis Impairs Monocyte Migration and Trains Macrophage Polarization in Long-term Treated HIV Infection

The paper identifies metabolic reprogramming in HIV-treated individuals that impairs monocyte migration and promotes M2-like macrophage polarization, enhancing HIV susceptibility.

TISSUE-SPECIFIC METABOLOMIC REPROGRAMMING DETERMINES THE DISEASE PATHOPHYSIOLOGY OF SARS-COV-2 VARIANTS IN HAMSTER MODEL

The paper investigates tissue-specific metabolic reprogramming and gut dysbiosis in hamsters infected with SARS-CoV-2 variants, revealing differences in viremia, metabolic responses, and microbiota composition between delta and omicron variants.