Sex-divergent brain epigenetic reprogramming by chronic opioids
Camille Falconnier, Alba Caparros-Roissard, Hanuš Slavík, Mithil Gaikwad, Victor Mathis, Margot Diringer, Charles Decraene, Salim Megat, Sebahat Ozkan, Mohamad Yassine, Yahia Hadj-Arab, Pierre Hener, Robin Waegaert, Brigitte Lina Kieffer, Emmanuel Darcq, , Pierre-Éric Lutz
This study identifies sex-specific epigenetic changes in the nucleus accumbens of male and female mice exposed to chronic morphine, revealing shared biological dysregulation and potential therapeutic targets.
bioRxiv · Oct 27, 2025 · PreprintNeuroscience