Pierre-Éric Lutz

The paper investigates sex differences in epigenetic changes linked to chronic pain-induced depression in mice, finding distinct genomic loci but shared regulatory features and gene modules across sexes.

This paper systematically reviews the role of DNA methylation and its enzymatic machinery in rodent models of substance use disorders, finding bidirectional effects and widespread reprogramming outside promoter regions.

This study identifies sex-specific epigenetic changes in the nucleus accumbens of male and female mice exposed to chronic morphine, revealing shared biological dysregulation and potential therapeutic targets.

This study reviews functional genomic mechanisms of opioid action and OUD across animal models and human studies, finding low consistency in gene expression results.

This study identifies the BLA-ACC pathway as critical for chronic pain-induced depression and reveals Sema4a's role in mood regulation through myelination impairments.

The paper investigates how early-life adversity affects epigenetic layers and gene expression in the amygdala, finding associations with immune and small GTPase dysregulation.

The paper investigates increased mu opioid receptor (MOR) functional coupling in the anterior insula of depressed individuals, linking it to increased expression of the inhibitory G-protein subunit GNAI2.

The paper investigates decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides using immunofluorescence, confocal imaging, and RNA-sequencing.