Sex differences in epigenetic mechanisms of chronic pain-induced depression
Mithil Gaikwad, Vandana Shree Vedartham Srinivasan, Beyza Ayazgök, Mathieu Bruggeman, Heba Elseedy, Hanuš Slavík, Alba Caparros-Roissard, Yahia Hadj-Arab, Khaled Abdallah, Noémie Willem, Stéphanie Le Gras, Benoît Labonté, İpek Yalçın, Pierre-Éric Lutz
The paper investigates sex differences in epigenetic changes linked to chronic pain-induced depression in mice, finding distinct genomic loci but shared regulatory features and gene modules across sexes.
bioRxiv · Jul 9, 2026 · PreprintNeuroscience