Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder
Shun‐Neng Hsu, Louise A. Stephen, Kanchan Phadwal, Scott Dillon, Roderick Carter, Nicholas M. Morton, Ineke H. N. Luijten, Katie Emelianova, Anish K. Amin, Vicky Elizabeth MacRae, Tom C. Freeman, Yu‐Juei Hsu, Katherine Ann Staines, Colin Farquharson
This study identifies mitochondrial dysfunction and impaired mitophagy in CKD-MBD as contributors to renal osteodystrophy, showing reversible effects with rapamycin treatment.
Kidney International · Feb 6, 2025Peer-reviewedGenomics