Deletion of a conserved zebrafish Gata2 enhancer impairs haemogenic endothelium programming and adult haematopoiesis
Tomasz Dobrzycki, Christopher B. Mahony, Mónika Krecsmarik, Cansu Koyunlar, Rossella Rispoli, Joke Zink, Kirsten J. Gussinklo, Bakhta Fedlaoui, Emma de Pater, Roger K. Patient, Rui M. Monteiro
This study shows that deleting a conserved zebrafish Gata2 enhancer impairs haemogenic endothelium programming and adult haematopoiesis, leading to bone marrow failure and immune defects.
bioRxiv · Dec 10, 2019 · PreprintDevelopmental Biology