Roger K. Patient

This study shows that Runx1 inhibits heart regeneration in zebrafish by promoting scar formation and reducing myocardial proliferation and survival.

This study identifies three distinct epicardial subpopulations in developing zebrafish hearts using single-cell RNA-sequencing and reveals their unique functions in cell adhesion, migration, and leukocyte recruitment.

This study shows that deleting a conserved zebrafish Gata2 enhancer impairs haemogenic endothelium programming and adult haematopoiesis, leading to bone marrow failure and immune defects.

The paper shows Etv6 regulates vegfa expression in Xenopus blood stem cells by both repressing foxo3 and activating klf4, with Klf4 recruiting Etv6 to the vegfa promoter.

The paper describes an optimized pipeline for genotyping zebrafish embryos after in situ hybridization and digitally quantifying gene expression, improving accuracy and reducing bias.

The paper shows that CBFβ can regulate gene expression independently of Runx, challenging the dogma that CBFβ's gene regulatory functions require Runx binding.