Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibility
Ethan L. Ostrom, Rudy Stuppard, Aurora Mattson-Hughes, David Joseph Marcinek
This study shows that inducible SOD2 knockdown in mouse skeletal muscle reduces metabolic flexibility by impairing pyruvate oxidation, with reversible effects upon recovery.
Free Radical Biology and Medicine · Nov 15, 2024Peer-reviewedPhysiology