Juan D. Chavez

This study combines quantitative proteomics and interactomics to analyze molecular differences between three human cell lines, revealing cell-type-specific changes in protein interactions and conformations.

The paper uses XL-MS and iqPIR to compare mitochondrial protein interactions in healthy and failing murine hearts, identifying structural changes in metabolic machinery.

The paper uses isotope-labeled crosslinkers to analyze protein interactions and posttranslational modifications in Diaphorina citri across life stages, revealing developmental changes in chromatin structure.

This study identifies SS-31 interacting proteins in mitochondria using chemical cross-linking and mass spectrometry, revealing their roles in ATP production and 2-oxoglutarate metabolism.

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.

The paper improves protein-protein docking by integrating cross-linking data, enhancing prediction accuracy and reducing false positives.