Matthew D. Campbell

This study isolates podocyte mitochondria from mice to show they have higher respiratory capacity than tubule mitochondria, with age- and sex-dependent differences.

The paper uses cross-linking to study mitochondrial interactome changes in aging mouse muscle, finding age-related shifts in protein interactions linked to functional decline.

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.

This study identifies SS-31 interacting proteins in mitochondria using chemical cross-linking and mass spectrometry, revealing their roles in ATP production and 2-oxoglutarate metabolism.