Sébastien Dubuis

This study identifies a metabolic tradeoff between fast growth and flexibility in cancer cells and stem cells by analyzing glutamine and aspartate metabolism.

The paper profiles the metabolome of 180 cancer cell lines and identifies two major metabolic types linked to epithelial-mesenchymal transition (EMT).

The paper maps TF-metabolite associations in cancer using a combined computational-experimental framework, revealing diverse TF dependencies in carbon metabolism.

This paper introduces a framework for large-scale dynamic metabolome drug profiling in mammalian cells, demonstrating its application to study dichloroacetate's toxic effects in ovarian cancer cell lines.