High-grade serous ovarian carcinoma organoids as models of chromosomal instability
M. Vias, L. Morrill Gavarro, C. M. Sauer, D. Sanders, A. M. Piskorz, D.-L. Couturier, S. Ballereau, B. Hernando, J. Hall, F. Correia-Martins, F. Markowetz, G. Macintyre, J. D. Brenton
This study develops HGSOC patient-derived organoids to model chromosomal instability and its mutational processes, showing they represent different causes of instability and can be used for drug sensitivity testing.
bioRxiv · Sep 1, 2022Cancer Biology